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Semaglutide therapy and diuretic use in obesity-related HFpEF
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Semaglutide and diuretic use in obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF-DM trials semaglutide improved HF-related symptoms and physical limitations across diuretic use subgroups
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Semaglutide lowers blood pressure via GLP-1 receptors on vascular smooth muscle, not via endothelial or immune pathways. There is a direct vasorelaxant mechanism linking GLP-1R activation to BP and…
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